Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cells

Fumarate hydratase (FH) is an enzyme in the tricarboxylic acid (TCA) cycle, biallelic loss-of-function mutations of which are associated with hereditary leiomyomatosis and renal cell cancer. However, how FH defect modulates intracellular metabolic fluxes in human cells has remained unclear. This stu...

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Detalles Bibliográficos
Autores principales: Noguchi, Shingo, Ishikawa, Hirokazu, Wakita, Kenichi, Matsuda, Fumio, Shimizu, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400513/
https://www.ncbi.nlm.nih.gov/pubmed/32747645
http://dx.doi.org/10.1038/s41598-020-70000-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400513/
https://www.ncbi.nlm.nih.gov/pubmed/32747645
http://dx.doi.org/10.1038/s41598-020-70000-6

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