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Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cells
Fumarate hydratase (FH) is an enzyme in the tricarboxylic acid (TCA) cycle, biallelic loss-of-function mutations of which are associated with hereditary leiomyomatosis and renal cell cancer. However, how FH defect modulates intracellular metabolic fluxes in human cells has remained unclear. This stu...
Autores principales: | Noguchi, Shingo, Ishikawa, Hirokazu, Wakita, Kenichi, Matsuda, Fumio, Shimizu, Hiroshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400513/ https://www.ncbi.nlm.nih.gov/pubmed/32747645 http://dx.doi.org/10.1038/s41598-020-70000-6 |
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