Ligand-bound glutamine binding protein assumes multiple metastable binding sites with different binding affinities

Protein dynamics plays key roles in ligand binding. However, the microscopic description of conformational dynamics-coupled ligand binding remains a challenge. In this study, we integrate molecular dynamics simulations, Markov state model (MSM) analysis and experimental methods to characterize the c...

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Detalles Bibliográficos
Autores principales: Zhang, Lu, Wu, Shaowen, Feng, Yitao, Wang, Dan, Jia, Xilin, Liu, Zhijun, Liu, Jianwei, Wang, Wenning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400645/
https://www.ncbi.nlm.nih.gov/pubmed/32747735
http://dx.doi.org/10.1038/s42003-020-01149-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400645/
https://www.ncbi.nlm.nih.gov/pubmed/32747735
http://dx.doi.org/10.1038/s42003-020-01149-z

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