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Ligand-bound glutamine binding protein assumes multiple metastable binding sites with different binding affinities
Protein dynamics plays key roles in ligand binding. However, the microscopic description of conformational dynamics-coupled ligand binding remains a challenge. In this study, we integrate molecular dynamics simulations, Markov state model (MSM) analysis and experimental methods to characterize the c...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400645/ https://www.ncbi.nlm.nih.gov/pubmed/32747735 http://dx.doi.org/10.1038/s42003-020-01149-z |