Mutational signature SBS8 predominantly arises due to late replication errors in cancer

Although a majority of somatic mutations in cancer are passengers, their mutational signatures provide mechanistic insights into mutagenesis and DNA repair processes. Mutational signature SBS8 is common in most cancers, but its etiology is debated. Incorporating genomic, epigenomic, and cellular pro...

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Detalles Bibliográficos
Autores principales: Singh, Vinod Kumar, Rastogi, Arnav, Hu, Xiaoju, Wang, Yaqun, De, Subhajyoti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400754/
https://www.ncbi.nlm.nih.gov/pubmed/32747711
http://dx.doi.org/10.1038/s42003-020-01119-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400754/
https://www.ncbi.nlm.nih.gov/pubmed/32747711
http://dx.doi.org/10.1038/s42003-020-01119-5

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