BRAF inhibition curtails IFN‐gamma‐inducible PD‐L1 expression and upregulates the immunoregulatory protein galectin‐1 in melanoma cells

Although melanoma is considered one of the most immunogenic malignancies, spontaneous T‐cell responses to melanoma antigens are ineffective due to tumor cell‐intrinsic or microenvironment‐driven immune evasion mechanisms. For example, oncogenic BRAF V600E mutation in melanoma cells fosters tumor imm...

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Detalles Bibliográficos
Autores principales: Górniak, Patryk, Wasylecka‐Juszczyńska, Maja, Ługowska, Iwona, Rutkowski, Piotr, Polak, Anna, Szydłowski, Maciej, Juszczyński, Przemysław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400781/
https://www.ncbi.nlm.nih.gov/pubmed/32330348
http://dx.doi.org/10.1002/1878-0261.12695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400781/
https://www.ncbi.nlm.nih.gov/pubmed/32330348
http://dx.doi.org/10.1002/1878-0261.12695

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