Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53‐associated features

TP53 gene mutations are very common in human cancer. While such mutations abrogate the tumor suppressive activities of the wild‐type (wt) p53 protein, some of them also endow the mutant (mut) protein with oncogenic gain of function (GOF), facilitating cancer progression. Yet, p53 may acquire altered...

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Detalles Bibliográficos
Autores principales: Benor, Gal, Fuks, Garold, Chin, Suet‐Feung, Rueda, Oscar M., Mukherjee, Saptaparna, Arandkar, Sharathchandra, Aylon, Yael, Caldas, Carlos, Domany, Eytan, Oren, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400784/
https://www.ncbi.nlm.nih.gov/pubmed/32484602
http://dx.doi.org/10.1002/1878-0261.12736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400784/
https://www.ncbi.nlm.nih.gov/pubmed/32484602
http://dx.doi.org/10.1002/1878-0261.12736

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