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Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53‐associated features
TP53 gene mutations are very common in human cancer. While such mutations abrogate the tumor suppressive activities of the wild‐type (wt) p53 protein, some of them also endow the mutant (mut) protein with oncogenic gain of function (GOF), facilitating cancer progression. Yet, p53 may acquire altered...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400784/ https://www.ncbi.nlm.nih.gov/pubmed/32484602 http://dx.doi.org/10.1002/1878-0261.12736 |