Role of ultraviolet mutational signature versus tumor mutation burden in predicting response to immunotherapy

Hydrophobic neoantigens are more immunogenic because they are better presented by the major histocompatibility complex and better recognized by T cells. Tumor cells can evade the immune response by expressing checkpoints such as programmed death ligand 1. Checkpoint blockade reactivates immune recog...

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Detalles Bibliográficos
Autores principales: Pham, Timothy V., Boichard, Amélie, Goodman, Aaron, Riviere, Paul, Yeerna, Huwate, Tamayo, Pablo, Kurzrock, Razelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400787/
https://www.ncbi.nlm.nih.gov/pubmed/32530570
http://dx.doi.org/10.1002/1878-0261.12748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400787/
https://www.ncbi.nlm.nih.gov/pubmed/32530570
http://dx.doi.org/10.1002/1878-0261.12748

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