Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities in large‐scale CHO‐based processes

Large‐scale bioreactors for the production of monoclonal antibodies reach volumes of up to 25 000 L. With increasing bioreactor size, mixing is however affected negatively, resulting in the formation of gradients throughout the reactor. These gradients can adversely affect process performance at lar...

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Detalles Bibliográficos
Autores principales: Paul, Katrin, Böttinger, Katharina, Mitic, Bernd M., Scherfler, Georg, Posch, Christoph, Behrens, Dirk, Huber, Christian G., Herwig, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401239/
https://www.ncbi.nlm.nih.gov/pubmed/32774209
http://dx.doi.org/10.1002/elsc.202000009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401239/
https://www.ncbi.nlm.nih.gov/pubmed/32774209
http://dx.doi.org/10.1002/elsc.202000009

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