Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations

Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)(2)(β2)(3) nAChR subunit arrangement comprises a pair of α3(+)β2(−) and β2(+)...

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Detalles Bibliográficos
Autores principales: Wen, Jierong, Adams, David J., Hung, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401271/
https://www.ncbi.nlm.nih.gov/pubmed/32635340
http://dx.doi.org/10.3390/md18070349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401271/
https://www.ncbi.nlm.nih.gov/pubmed/32635340
http://dx.doi.org/10.3390/md18070349

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