Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole

Given our previous finding that fluorination at the C18 position of largazole showed reasonably good tolerance towards inhibitory activity and selectivity of histone deacetylases (HDACs), further modification on the valine residue in the fluoro-largazole’s macrocyclic moiety with S-Me l-Cysteine or...

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Detalles Bibliográficos
Autores principales: Zhang, Bingbing, Ruan, Zhu-Wei, Luo, Dongdong, Zhu, Yueyue, Ding, Tingbo, Sui, Qiang, Lei, Xinsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401273/
https://www.ncbi.nlm.nih.gov/pubmed/32629787
http://dx.doi.org/10.3390/md18070344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401273/
https://www.ncbi.nlm.nih.gov/pubmed/32629787
http://dx.doi.org/10.3390/md18070344

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