Metabolism of JQ1, an inhibitor of bromodomain and extra terminal bromodomain proteins, in human and mouse liver microsomes

JQ1 is a small-molecule inhibitor of the bromodomain and extra terminal (BET) protein family that potently inhibits the bromodomain testis-specific protein (BRDT), which is essential for spermatogenesis. JQ1 treatment produces a reversible contraceptive effect by targeting the activity of BRDT in mo...

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Detalles Bibliográficos
Autores principales: Li, Feng, MacKenzie, Kevin R, Jain, Prashi, Santini, Conrad, Young, Damian W, Matzuk, Martin M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Contraceptive Special Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401416/
https://www.ncbi.nlm.nih.gov/pubmed/32285106
http://dx.doi.org/10.1093/biolre/ioaa043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401416/
https://www.ncbi.nlm.nih.gov/pubmed/32285106
http://dx.doi.org/10.1093/biolre/ioaa043

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