Cargando…

Metabolism of JQ1, an inhibitor of bromodomain and extra terminal bromodomain proteins, in human and mouse liver microsomes

JQ1 is a small-molecule inhibitor of the bromodomain and extra terminal (BET) protein family that potently inhibits the bromodomain testis-specific protein (BRDT), which is essential for spermatogenesis. JQ1 treatment produces a reversible contraceptive effect by targeting the activity of BRDT in mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Feng, MacKenzie, Kevin R, Jain, Prashi, Santini, Conrad, Young, Damian W, Matzuk, Martin M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Contraceptive Special Issue
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401416/ https://www.ncbi.nlm.nih.gov/pubmed/32285106 http://dx.doi.org/10.1093/biolre/ioaa043

Ejemplares similares

Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice
por: Devlin, Darius J, et al.
Publicado: (2020)

CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity
por: Park, Soojin, et al.
Publicado: (2020)

Prss55 but not Prss51 is required for male fertility in mice
por: Kobayashi, Kiyonori, et al.
Publicado: (2020)

Tmprss12 is required for sperm motility and uterotubal junction migration in mice(†)
por: Larasati, Tamara, et al.
Publicado: (2020)

CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction(†)
por: Sun, Jiang, et al.
Publicado: (2020)

BET bromodomain inhibitor (JQ1) and tumor angiogenesis
por: Bid, Hemant Kumar, et al.
Publicado: (2016)

CIB4 is essential for the haploid phase of spermatogenesis in mice
por: Xu, Zoulan, et al.
Publicado: (2020)

Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice(†)
por: Nozawa, Kaori, et al.
Publicado: (2020)

Bromodomain and extra‐terminal protein mimic JQ1 decreases inflammation in human vascular endothelial cells: Implications for pulmonary arterial hypertension
por: Mumby, Sharon, et al.
Publicado: (2016)

Bromodomains and Extra-Terminal (BET) Inhibitor JQ1 Suppresses Proliferation of Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolysis
por: Zhang, Meng-Yi, et al.
Publicado: (2020)

Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production
por: Gibbons, Hunter R., et al.
Publicado: (2019)

The role of team science in the future of male contraception
por: Vahdat, Heather L, et al.
Publicado: (2020)

Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases
por: Wu, Dayu, et al.
Publicado: (2022)

Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis
por: Fu, Rong, et al.
Publicado: (2022)

Discovery of Benzo[d]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain
por: Cipriano, Alessandra, et al.
Publicado: (2022)

Engineering monoclonal antibody-based contraception and multipurpose prevention technologies(†)
por: Anderson, Deborah J, et al.
Publicado: (2020)

The BET-bromodomain inhibitor JQ1 mitigates vemurafenib drug resistance in melanoma
por: Zhao, Bei, et al.
Publicado: (2018)

Bromodomain Inhibitor JQ1 Provides Novel Insights and Perspectives in Rhabdomyosarcoma Treatment
por: Marchesi, Irene, et al.
Publicado: (2022)

Provision of immediate postpartum intrauterine contraception after vaginal birth within a public maternity setting: Health services research evaluation
por: Cooper, Michelle, et al.
Publicado: (2019)

BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis
por: Wang, Xiaorong, et al.
Publicado: (2021)

Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation
por: Trivedi, Archit, et al.
Publicado: (2020)

Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases
por: Kulikowski, Ewelina, et al.
Publicado: (2020)

Prognostic role of overexpressed Bromodomain and extra-terminal family in ovarian cancer
por: Chetry, Mandika, et al.
Publicado: (2022)

Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors
por: Flynn, Noah R., et al.
Publicado: (2021)

Mechanism of semen liquefaction and its potential for a novel non-hormonal contraception(†)
por: Anamthathmakula, Prashanth, et al.
Publicado: (2020)

A cell-based high-content screen identifies isocotoin as a small molecule inhibitor of the meiosis-specific MEIOB–SPATA22 complex(†)
por: Xu, Yang, et al.
Publicado: (2020)

Review of rationale and progress toward targeting cyclin-dependent kinase 2 (CDK2) for male contraception(†)
por: Faber, Erik B, et al.
Publicado: (2020)

Synthesis of 2-phenyl-5,6,7,8-tetrahydroquinoxaline derivatives and screening for P2X1-purinoceptor antagonist activity in isolated preparations of rat vas deferens, for translation into a male contraceptive
por: Mathiew, Mitch, et al.
Publicado: (2020)

Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration(†)
por: Balbach, Melanie, et al.
Publicado: (2020)

Testis-specific serine kinase protein family in male fertility and as targets for non-hormonal male contraception
por: Salicioni, Ana M, et al.
Publicado: (2020)

The Na(+) and K(+) transport system of sperm (ATP1A4) is essential for male fertility and an attractive target for male contraception
por: Syeda, Shameem Sultana, et al.
Publicado: (2020)

The postcoital test in the development of new vaginal contraceptives
por: Mauck, Christine K, et al.
Publicado: (2020)

Exogenous sex steroids regulate genital epithelial barrier function in female rhesus macaques
por: Quispe Calla, Nirk E, et al.
Publicado: (2020)

Serine protease inhibitor disrupts sperm motility leading to reduced fertility in female mice(†)
por: Barton, Brooke E, et al.
Publicado: (2020)

HIV, progestins, genital epithelial barrier function, and the burden of objectivity
por: Vicetti Miguel, Rodolfo D, et al.
Publicado: (2020)

The new contraceptive revolution: developing innovative products outside of industry(†,‡)
por: Callahan, Rebecca L, et al.
Publicado: (2020)

Retinoic acid receptor antagonists for male contraception: current status(†)
por: Noman, Md Abdullah Al, et al.
Publicado: (2020)

Development of multipurpose technologies products for pregnancy and STI prevention: update on polyphenylene carboxymethylene MPT gel development(†)
por: Weitzel, Mary, et al.
Publicado: (2020)

Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis
por: Hanna, Carol B, et al.
Publicado: (2020)

Towards a roadmap to advance non-hormonal contraceptive multipurpose prevention technologies: strategic insights from key stakeholders(†)
por: Hemmerling, Anke, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_o9749018kho2rc6j5snrk0k8l1