TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology

PURPOSE: Elevated levels of transforming-growth-factor (TGF)-β2 in the trabecular meshwork (TM) and aqueous humor are associated with primary open-angle glaucoma (POAG). The underlying mechanism includes alteration of extracellular matrix homeostasis through Smad-dependent and independent signaling....

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Detalles Bibliográficos
Autores principales: Ashok, Ajay, Chaudhary, Suman, Kritikos, Alexander E., Kang, Min H., McDonald, Dallas, Rhee, Douglas J., Singh, Neena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Glaucoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401420/
https://www.ncbi.nlm.nih.gov/pubmed/32182331
http://dx.doi.org/10.1167/iovs.61.3.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401420/
https://www.ncbi.nlm.nih.gov/pubmed/32182331
http://dx.doi.org/10.1167/iovs.61.3.24

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