Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa

PURPOSE: Activating the cell survival modulator sigma 1 receptor (Sig1R) delays cone photoreceptor cell loss in Pde6βrd10/J (rd10) mice, a model of retinitis pigmentosa. Beneficial effects are abrogated in rd10 mice lacking NRF2, implicating NRF2 as essential to Sig1R-mediated cone neuroprotection....

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Detalles Bibliográficos
Autores principales: Xiao, Haiyan, Wang, Jing, Saul, Alan, Smith, Sylvia B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401726/
https://www.ncbi.nlm.nih.gov/pubmed/32150247
http://dx.doi.org/10.1167/iovs.61.3.5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401726/
https://www.ncbi.nlm.nih.gov/pubmed/32150247
http://dx.doi.org/10.1167/iovs.61.3.5

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