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SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration
Neuroinflammation and necroptosis are major contributors to neurodegenerative disease, and axon dysfunction and degeneration is often an initiating event. SARM1 is the central executioner of pathological axon degeneration. Here, we demonstrate functional and mechanistic links among these three pro-d...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401797/ https://www.ncbi.nlm.nih.gov/pubmed/32609299 http://dx.doi.org/10.1083/jcb.201912047 |