Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L

The main protease (M(pro)) of SARS-CoV-2, the pathogen responsible for the COVID-19 pandemic, is a key antiviral drug target. While most SARS-CoV-2 M(pro) inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently discovered several M(pro) inhibitors have hydrophobic moieties at...

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Detalles Bibliográficos
Autores principales: Sacco, Michael Dominic, Ma, Chunlong, Lagarias, Panagiotis, Gao, Ang, Townsend, Julia Alma, Meng, Xiangzhi, Dube, Peter, Zhang, Xiujun, Hu, Yanmei, Kitamura, Naoya, Hurst, Brett, Tarbet, Bart, Marty, Michael Thomas, Kolocouris, Antonios, Xiang, Yan, Chen, Yu, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402059/
https://www.ncbi.nlm.nih.gov/pubmed/32766590
http://dx.doi.org/10.1101/2020.07.27.223727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402059/
https://www.ncbi.nlm.nih.gov/pubmed/32766590
http://dx.doi.org/10.1101/2020.07.27.223727

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