Cargando…

Dauricine Protects from LPS-Induced Bone Loss via the ROS/PP2A/NF-κB Axis in Osteoclasts

Dauricine (DAC), an isoquinoline alkaloid, exhibits anti-inflammatory activity. We hypothesized that DAC may prevent the inflammatory bone loss induced by lipopolysaccharide (LPS). LPS-induced bone loss was decreased by DAC in female C57BL/6J mice as evaluated by micro-computerized tomography (μCT)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Hyun-Jung, Gholam Zadeh, Malihatosadat, Suh, Jae-Hee, Choi, Hye-Seon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402093/ https://www.ncbi.nlm.nih.gov/pubmed/32640590 http://dx.doi.org/10.3390/antiox9070588

Ejemplares similares

Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss
por: Park, Hyun-Jung, et al.
Publicado: (2019)

Estrogen Decreases Cytoskeletal Organization by Forming an ERα/SHP2/c-Src Complex in Osteoclasts to Protect against Ovariectomy-Induced Bone Loss in Mice
por: Park, Hyun-Jung, et al.
Publicado: (2021)

Morin Disrupts Cytoskeleton Reorganization in Osteoclasts through an ROS/SHP1/c-Src Axis and Grants Protection from LPS-Induced Bone Loss
por: Park, Hyun-Jung, et al.
Publicado: (2022)

Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
por: Hu, Ji, et al.
Publicado: (2021)

Corrigendum: Dauricine attenuates vascular endothelial inflammation through inhibiting NF-κB pathway
por: Hu, Ji, et al.
Publicado: (2023)

Doxorubicin Induces Bone Loss by Increasing Autophagy through a Mitochondrial ROS/TRPML1/TFEB Axis in Osteoclasts
por: Park, Hyun-Jung, et al.
Publicado: (2022)

Trimethylamine-N-Oxide Promotes Osteoclast Differentiation and Bone Loss via Activating ROS-Dependent NF-κB Signaling Pathway
por: Wang, Ning, et al.
Publicado: (2022)

Dauricine suppresses the growth of pancreatic cancer in vivo by modulating the Hedgehog signaling pathway
por: Zhang, Ying-Bo, et al.
Publicado: (2019)

High Cholesterol-Induced Bone Loss Is Attenuated by Arctiin via an Action in Osteoclasts
por: Li, Guoen, et al.
Publicado: (2022)

Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF-κB Axis
por: Han, Chenglin, et al.
Publicado: (2021)

Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis
por: Chen, Haitao, et al.
Publicado: (2023)

Intranasal administration of dauricine loaded on graphene oxide: multi-target therapy for Alzheimer's disease
por: Wang, Kaixuan, et al.
Publicado: (2021)

Herbal Compounds Dauricine and Isoliensinine Impede SARS-CoV-2 Viral Entry
por: Dabrell, Shaneek Natoya, et al.
Publicado: (2023)

Erratum to “Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF-κB Axis”
por: Han, Chenglin, et al.
Publicado: (2021)

Dehydrocostus lactone attenuates osteoclastogenesis and osteoclast‐induced bone loss by modulating NF‐κB signalling pathway
por: Hu, Bin, et al.
Publicado: (2019)

Alpinetin inhibits breast cancer growth by ROS/NF‐κB/HIF‐1α axis
por: Zhang, Tao, et al.
Publicado: (2020)

Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity
por: Wu, Ming-Yue, et al.
Publicado: (2017)

The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro
por: Liu, Pan, et al.
Publicado: (2018)

Protective Effects of Evodiamine against LPS-Induced Acute Kidney Injury through Regulation of ROS-NF-κB-Mediated Inflammation
por: Shi, Yan, et al.
Publicado: (2019)

CVB3 Inhibits NLRP3 Inflammasome Activation by Suppressing NF-κB Pathway and ROS Production in LPS-Induced Macrophages
por: Wang, Yanqi, et al.
Publicado: (2023)

Diphlorethohydroxycarmalol from Ishige okamurae Suppresses Osteoclast Differentiation by Downregulating the NF-κB Signaling Pathway
por: Ihn, Hye Jung, et al.
Publicado: (2017)

Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-κB and AP-1
por: Jeong, Gyu Won, et al.
Publicado: (2020)

Isoliensinine Suppresses Osteoclast Formation Through NF-κB Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss
por: Liu, Huijiang, et al.
Publicado: (2022)

Ceritinib (LDK378) prevents bone loss via suppressing Akt and NF-κB-induced osteoclast formation
por: He, Wenxin, et al.
Publicado: (2022)

Reciprocal Role of ERK and Nf-κb Pathways in Survival and Activation of Osteoclasts
por: Miyazaki, Tsuyoshi, et al.
Publicado: (2000)

Stachydrine prevents LPS‐induced bone loss by inhibiting osteoclastogenesis via NF‐κB and Akt signalling
por: Meng, Jiahong, et al.
Publicado: (2019)

Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF‐κB pathway
por: Li, Yajun, et al.
Publicado: (2022)

Ferulic acid alleviates retinal neovascularization by modulating microglia/macrophage polarization through the ROS/NF-κB axis
por: Sun, Xiaowei, et al.
Publicado: (2022)

Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NF-κB Axis
por: Qu, Yifan, et al.
Publicado: (2021)

Transcriptional profiling of the LPS induced NF-κB response in macrophages
por: Sharif, Omar, et al.
Publicado: (2007)

Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation
por: Lo, Jung, et al.
Publicado: (2022)

Anti-Rheumatic Properties of Gentiopicroside Are Associated With Suppression of ROS-NF-κB-NLRP3 Axis in Fibroblast-Like Synoviocytes and NF-κB Pathway in Adjuvant-Induced Arthritis
por: Wang, Meiling, et al.
Publicado: (2020)

Interleukin-17A upregulates receptor activator of NF-κB on osteoclast precursors
por: Adamopoulos, Iannis E, et al.
Publicado: (2010)

Inhibition of Osteoclast Differentiation by Carotenoid Derivatives through Inhibition of the NF-κB Pathway
por: Odes-Barth, Shlomit, et al.
Publicado: (2020)

Methanol Extract of Croton Pycnanthus Benth. Inhibits Osteoclast Differentiation by Suppressing the MAPK and NF-κB Signaling Pathways
por: Lee, Jiyeon, et al.
Publicado: (2014)

Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease
por: Chen, Chongyang, et al.
Publicado: (2021)

ROCK inhibitor fasudil reduces the expression of inflammatory factors in LPS-induced rat pulmonary microvascular endothelial cells via ROS/NF-κB pathway
por: Liu, Huanlong, et al.
Publicado: (2022)

CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts
por: Greenblatt, Matthew B., et al.
Publicado: (2015)

Nur77 Prevents Osteoporosis by Inhibiting the NF‐κB Signalling Pathway and Osteoclast Differentiation
por: Tian, Huanlian, et al.
Publicado: (2022)

Nicorandil Inhibits Osteoclast Formation Base on NF-κB and p-38 MAPK Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss
por: Xu, Shenggui, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4v78uhu7bj3m0cefefrg0hul2n