Adeno-Associated Viral Transfer of Glyoxalase-1 Blunts Carbonyl and Oxidative Stresses in Hearts of Type 1 Diabetic Rats

Accumulation of methylglyoxal (MG) arising from downregulation of its primary degrading enzyme glyoxalase-1 (Glo1) is an underlying cause of diabetic cardiomyopathy (DC). This study investigated if expressing Glo1 in rat hearts shortly after the onset of Type 1 diabetes mellitus (T1DM) would blunt t...

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Detalles Bibliográficos
Autores principales: Alomar, Fadhel A., Al-Rubaish, Abdullah, Al-Muhanna, Fahad, Al-Ali, Amein K., McMillan, JoEllyn, Singh, Jaipaul, Bidasee, Keshore R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402150/
https://www.ncbi.nlm.nih.gov/pubmed/32640624
http://dx.doi.org/10.3390/antiox9070592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402150/
https://www.ncbi.nlm.nih.gov/pubmed/32640624
http://dx.doi.org/10.3390/antiox9070592

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