Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents

The current study presents the design, synthesis, and evaluation of novel cytochrome P450 17A1 (CYP17A1) ligands. CYP17A1 is a key enzyme in the steroidogenic pathway that produces androgens among other steroids, and it is implicated in prostate cancer. The obtained compounds are potent enzyme inhib...

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Detalles Bibliográficos
Autores principales: Wróbel, Tomasz M., Rogova, Oksana, Andersen, Kasper L., Yadav, Rahul, Brixius-Anderko, Simone, Scott, Emily E., Olsen, Lars, Jørgensen, Flemming Steen, Björkling, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402352/
https://www.ncbi.nlm.nih.gov/pubmed/32660148
http://dx.doi.org/10.3390/ijms21144868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402352/
https://www.ncbi.nlm.nih.gov/pubmed/32660148
http://dx.doi.org/10.3390/ijms21144868

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