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Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents

The current study presents the design, synthesis, and evaluation of novel cytochrome P450 17A1 (CYP17A1) ligands. CYP17A1 is a key enzyme in the steroidogenic pathway that produces androgens among other steroids, and it is implicated in prostate cancer. The obtained compounds are potent enzyme inhib...

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Detalles Bibliográficos
Autores principales:	Wróbel, Tomasz M., Rogova, Oksana, Andersen, Kasper L., Yadav, Rahul, Brixius-Anderko, Simone, Scott, Emily E., Olsen, Lars, Jørgensen, Flemming Steen, Björkling, Fredrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402352/ https://www.ncbi.nlm.nih.gov/pubmed/32660148 http://dx.doi.org/10.3390/ijms21144868

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