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Selection of chromatographic methods for the purification of cell culture-derived Orf virus for its application as a vaccine or viral vector

In recent years, the Orf virus has become a promising tool for protective recombinant vaccines and oncolytic therapy. However, suitable methods for an Orf virus production, including up- and downstream, are very limited. The presented study focuses on downstream processing, describing the evaluation...

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Detalles Bibliográficos
Autores principales: Lothert, Keven, Pagallies, Felix, Feger, Thomas, Amann, Ralf, Wolff, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403136/
https://www.ncbi.nlm.nih.gov/pubmed/32763261
http://dx.doi.org/10.1016/j.jbiotec.2020.07.023