Reduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis

Sepsis-associated liver dysfunction manifesting as cholestasis is common during multiple organ failure. Three hepatocytic dysfunctions are considered as major hallmarks of cholestasis in sepsis: impairments of microvilli covering canalicular membranes, disruptions of tight junctions sealing bile-col...

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Detalles Bibliográficos
Autores principales: Beer, Anne J., Hertz, David, Seemann, Eric, Beretta, Martina, Westermann, Martin, Bauer, Reinhard, Bauer, Michael, Kessels, Michael M., Qualmann, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403153/
https://www.ncbi.nlm.nih.gov/pubmed/32753644
http://dx.doi.org/10.1038/s41598-020-69901-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403153/
https://www.ncbi.nlm.nih.gov/pubmed/32753644
http://dx.doi.org/10.1038/s41598-020-69901-3

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