Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A promising solution may be the inhibition of coagulation factor XII (FXII), because its knock-out or inhibition in animals reduced thrombosis without causing abnormal bleeding. Herein, we have engineered a mac...

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Detalles Bibliográficos
Autores principales: Wilbs, Jonas, Kong, Xu-Dong, Middendorp, Simon J., Prince, Raja, Cooke, Alida, Demarest, Caitlin T., Abdelhafez, Mai M., Roberts, Kalliope, Umei, Nao, Gonschorek, Patrick, Lamers, Christina, Deyle, Kaycie, Rieben, Robert, Cook, Keith E., Angelillo-Scherrer, Anne, Heinis, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403315/
https://www.ncbi.nlm.nih.gov/pubmed/32753636
http://dx.doi.org/10.1038/s41467-020-17648-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403315/
https://www.ncbi.nlm.nih.gov/pubmed/32753636
http://dx.doi.org/10.1038/s41467-020-17648-w

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