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Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A promising solution may be the inhibition of coagulation factor XII (FXII), because its knock-out or inhibition in animals reduced thrombosis without causing abnormal bleeding. Herein, we have engineered a mac...
Autores principales: | Wilbs, Jonas, Kong, Xu-Dong, Middendorp, Simon J., Prince, Raja, Cooke, Alida, Demarest, Caitlin T., Abdelhafez, Mai M., Roberts, Kalliope, Umei, Nao, Gonschorek, Patrick, Lamers, Christina, Deyle, Kaycie, Rieben, Robert, Cook, Keith E., Angelillo-Scherrer, Anne, Heinis, Christian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403315/ https://www.ncbi.nlm.nih.gov/pubmed/32753636 http://dx.doi.org/10.1038/s41467-020-17648-w |
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