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Optimisation of Tet-On inducible systems for Sleeping Beauty-based chimeric antigen receptor (CAR) applications

Regulated expression of genetic elements that either encode polypeptides or various types of functional RNA is a fundamental goal for gene therapy. Inducible expression may be preferred over constitutive promoters to allow clinician-based control of gene expression. Existing Tet-On systems represent...

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Detalles Bibliográficos
Autores principales: Ali Hosseini Rad, S. M., Poudel, Aarati, Tan, Grace Min Yi, McLellan, Alexander D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403325/
https://www.ncbi.nlm.nih.gov/pubmed/32753634
http://dx.doi.org/10.1038/s41598-020-70022-0