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Omental adipocytes promote peritoneal metastasis of gastric cancer through the CXCL2–VEGFA axis

BACKGROUND: Gastric cancer (GC) patients frequently develop peritoneal metastasis; however, the underlying mechanism remains unknown. We hypothesised that omental adipocytes (OmAd) trigger GC cells towards malignant activity to induce peritoneal metastasis. METHODS: We analysed interactions among hu...

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Detalles Bibliográficos
Autores principales: Natsume, Makoto, Shimura, Takaya, Iwasaki, Hiroyasu, Okuda, Yusuke, Hayashi, Kazuki, Takahashi, Satoru, Kataoka, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403422/
https://www.ncbi.nlm.nih.gov/pubmed/32439934
http://dx.doi.org/10.1038/s41416-020-0898-3