CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage

The CDC7 kinase is essential for the activation of DNA replication origins and has been implicated in the replication stress response. Using a highly specific chemical inhibitor and a chemical genetic approach, we now show that CDC7 activity is required to coordinate multiple MRE11‐dependent process...

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Detalles Bibliográficos
Autores principales: Rainey, Michael D, Quinlan, Aisling, Cazzaniga, Chiara, Mijic, Sofija, Martella, Oliviano, Krietsch, Jana, Göder, Anja, Lopes, Massimo, Santocanale, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403700/
https://www.ncbi.nlm.nih.gov/pubmed/32496651
http://dx.doi.org/10.15252/embr.201948920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403700/
https://www.ncbi.nlm.nih.gov/pubmed/32496651
http://dx.doi.org/10.15252/embr.201948920

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