Dual Inhibition of CDK4/6 and PI3K/AKT/mTOR Signaling Impairs Energy Metabolism in MPM Cancer Cells

Background: Malignant pleural mesothelioma (MPM) is an aggressive malignancy associated to asbestos exposure. One of the most frequent genetic alteration in MPM patients is CDKN2A/ARF loss, leading to aberrant activation of the Rb pathway. In MPM cells, we previously demonstrated the therapeutic eff...

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Detalles Bibliográficos
Autores principales: Bonelli, Mara, Terenziani, Rita, Zoppi, Silvia, Fumarola, Claudia, La Monica, Silvia, Cretella, Daniele, Alfieri, Roberta, Cavazzoni, Andrea, Digiacomo, Graziana, Galetti, Maricla, Petronini, Pier Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403976/
https://www.ncbi.nlm.nih.gov/pubmed/32708306
http://dx.doi.org/10.3390/ijms21145165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403976/
https://www.ncbi.nlm.nih.gov/pubmed/32708306
http://dx.doi.org/10.3390/ijms21145165

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