Anti-Inflammatory Effects of the Novel PIM Kinase Inhibitor KMU-470 in RAW 264.7 Cells through the TLR4-NF-κB-NLRP3 Pathway

PIM kinases, a small family of serine/threonine kinases, are important intermediates in the cytokine signaling pathway of inflammatory disease. In this study, we investigated whether the novel PIM kinase inhibitor KMU-470, a derivative of indolin-2-one, inhibits lipopolysaccharide (LPS)-induced infl...

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Detalles Bibliográficos
Autores principales: Baek, Hye Suk, Min, Hyeon Ji, Hong, Victor Sukbong, Kwon, Taeg Kyu, Park, Jong Wook, Lee, Jinho, Kim, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403980/
https://www.ncbi.nlm.nih.gov/pubmed/32698512
http://dx.doi.org/10.3390/ijms21145138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403980/
https://www.ncbi.nlm.nih.gov/pubmed/32698512
http://dx.doi.org/10.3390/ijms21145138

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