A Novel Methoxybenzyl 5-Nitroacridone Derivative Effectively Triggers G1 Cell Cycle Arrest in Chronic Myelogenous Leukemia K562 Cells by Inhibiting CDK4/6-Mediated Phosphorylation of Rb

Chronic myeloid leukemia (CML) is a malignant tumor caused by the abnormal proliferation of hematopoietic stem cells. Among a new series of acridone derivatives previously synthesized, it was found that the methoxybenzyl 5-nitroacridone derivative 8q has nanomolar cytotoxicity in vitro against human...

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Detalles Bibliográficos
Autores principales: Zhang, Bin, Zhang, Ting, Zhang, Tian-Yi, Wang, Ning, He, Shan, Wu, Bin, Jin, Hai-Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403985/
https://www.ncbi.nlm.nih.gov/pubmed/32708403
http://dx.doi.org/10.3390/ijms21145077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403985/
https://www.ncbi.nlm.nih.gov/pubmed/32708403
http://dx.doi.org/10.3390/ijms21145077

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