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A Novel Methoxybenzyl 5-Nitroacridone Derivative Effectively Triggers G1 Cell Cycle Arrest in Chronic Myelogenous Leukemia K562 Cells by Inhibiting CDK4/6-Mediated Phosphorylation of Rb

Chronic myeloid leukemia (CML) is a malignant tumor caused by the abnormal proliferation of hematopoietic stem cells. Among a new series of acridone derivatives previously synthesized, it was found that the methoxybenzyl 5-nitroacridone derivative 8q has nanomolar cytotoxicity in vitro against human...

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Detalles Bibliográficos
Autores principales:	Zhang, Bin, Zhang, Ting, Zhang, Tian-Yi, Wang, Ning, He, Shan, Wu, Bin, Jin, Hai-Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403985/ https://www.ncbi.nlm.nih.gov/pubmed/32708403 http://dx.doi.org/10.3390/ijms21145077

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