Proteomics Reveals that Methylmalonyl-CoA Mutase Modulates Cell Architecture and Increases Susceptibility to Stress

Methylmalonic acidemia (MMA) is a rare inborn error of metabolism caused by deficiency of the methylmalonyl-CoA mutase (MUT) enzyme. Downstream MUT deficiency, methylmalonic acid accumulates together with toxic metabolites from propionyl-CoA and other compounds upstream of the block in the enzyme pa...

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Detalles Bibliográficos
Autores principales: Costanzo, Michele, Caterino, Marianna, Cevenini, Armando, Jung, Vincent, Chhuon, Cerina, Lipecka, Joanna, Fedele, Roberta, Guerrera, Ida Chiara, Ruoppolo, Margherita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403994/
https://www.ncbi.nlm.nih.gov/pubmed/32679819
http://dx.doi.org/10.3390/ijms21144998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403994/
https://www.ncbi.nlm.nih.gov/pubmed/32679819
http://dx.doi.org/10.3390/ijms21144998

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