A Novel Synthetic Compound (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile Inhibits TNFα-Induced MMP9 Expression via EGR-1 Downregulation in MDA-MB-231 Human Breast Cancer Cells

Breast cancer is a common malignancy among women worldwide. Gelatinases such as matrix metallopeptidase 2 (MMP2) and MMP9 play crucial roles in cancer cell migration, invasion, and metastasis. To develop a novel platform compound, we synthesized a flavonoid derivative, (E)-5-((4-oxo-4H-chromen-3-yl)...

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Detalles Bibliográficos
Autores principales: Jeong, Munki, Jung, Euitaek, Lee, Young Han, Seo, Jeong Kon, Ahn, Seunghyun, Koh, Dongsoo, Lim, Yoongho, Shin, Soon Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404000/
https://www.ncbi.nlm.nih.gov/pubmed/32708426
http://dx.doi.org/10.3390/ijms21145080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404000/
https://www.ncbi.nlm.nih.gov/pubmed/32708426
http://dx.doi.org/10.3390/ijms21145080

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