Mid-Gestation lethality of Atxn2l-Ablated Mice

Depletion of yeast/fly Ataxin-2 rescues TDP-43 overexpression toxicity. In mouse models of Amyotrophic Lateral Sclerosis via TDP-43 overexpression, depletion of its ortholog ATXN2 mitigated motor neuron degeneration and extended lifespan from 25 days to >300 days. There is another ortholog in mam...

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Detalles Bibliográficos
Autores principales: Key, Jana, Harter, Patrick N., Sen, Nesli-Ece, Gradhand, Elise, Auburger, Georg, Gispert, Suzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404131/
https://www.ncbi.nlm.nih.gov/pubmed/32698485
http://dx.doi.org/10.3390/ijms21145124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404131/
https://www.ncbi.nlm.nih.gov/pubmed/32698485
http://dx.doi.org/10.3390/ijms21145124

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