Cargando…

Development of a Single Construct System for Site-Directed RNA Editing Using MS2-ADAR

Site-directed RNA editing (SDRE) technologies have great potential for treating genetic diseases caused by point mutations. Our group and other researchers have developed SDRE methods utilizing adenosine deaminases acting on RNA (ADARs) and guide RNAs recruiting ADARs to target RNAs bearing point mu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tohama, Tetsuto, Sakari, Matomo, Tsukahara, Toshifumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404196/ https://www.ncbi.nlm.nih.gov/pubmed/32668759 http://dx.doi.org/10.3390/ijms21144943

Ejemplares similares

Examination of Factors Affecting Site-Directed RNA Editing by the MS2-ADAR1 Deaminase System
por: Azad, Md Thoufic Anam, et al.
Publicado: (2023)

RNA editing of BFP, a point mutant of GFP, using artificial APOBEC1 deaminase to restore the genetic code
por: Bhakta, Sonali, et al.
Publicado: (2020)

Genome-Wide Identification of U-To-C RNA Editing Events for Nuclear Genes in Arabidopsis thaliana
por: Ruchika,, et al.
Publicado: (2021)

The Role of the Exonic lncRNA PRKDC-210 in Transcription Regulation
por: Mo, Junling, et al.
Publicado: (2022)

C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code
por: Bhakta, Sonali, et al.
Publicado: (2022)

Predicting sites of ADAR editing in double-stranded RNA
por: Eggington, Julie M., et al.
Publicado: (2011)

Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells
por: , Saifullah, et al.
Publicado: (2020)

Applying Human ADAR1p110 and ADAR1p150 for Site-Directed RNA Editing—G/C Substitution Stabilizes GuideRNAs against Editing
por: Heep, Madeleine, et al.
Publicado: (2017)

The ADAR Family in Amphioxus: RNA Editing and Conserved Orthologous Site Predictions
por: Zawisza-Álvarez, Michał, et al.
Publicado: (2020)

Promoting RNA editing by ADAR attraction
por: Danan-Gotthold, Miri, et al.
Publicado: (2017)

ADAR RNA editing below the backbone
por: Keegan, Liam, et al.
Publicado: (2017)

Cleavage of dsRNAs hyper-edited by ADARs occurs at preferred editing sites
por: Scadden, A. D. J., et al.
Publicado: (2005)

RNA editing enzyme ADAR1 is required for early T cell development
Publicado: (2022)

RNA editing enzyme ADAR1 is required for early T cell development
por: Xufeng, Richard, et al.
Publicado: (2020)

Novel Engineered Programmable Systems for ADAR-Mediated RNA Editing
por: Aquino-Jarquin, Guillermo
Publicado: (2020)

The origin of the ADAR gene family and animal RNA editing
por: Grice, Laura F, et al.
Publicado: (2015)

RNA Editing, ADAR1, and the Innate Immune Response
por: Wang, Qingde, et al.
Publicado: (2017)

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
por: Walkley, Carl R., et al.
Publicado: (2017)

Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes
por: Keegan, Liam P, et al.
Publicado: (2004)

A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing
por: Costa Cruz, Pedro Henrique, et al.
Publicado: (2020)

Lessons from discovery of true ADAR RNA editing sites in a human cell line
por: Wang, Fang, et al.
Publicado: (2023)

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms
por: Kleinova, Renata, et al.
Publicado: (2023)

Editing independent effects of ADARs on the miRNA/siRNA pathways
por: Heale, Bret S E, et al.
Publicado: (2009)

Modulation of ADAR1 editing activity by Z-RNA in vitro
por: Koeris, Michael, et al.
Publicado: (2005)

ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression
por: Wang, Isabel X., et al.
Publicado: (2013)

Complex regulation of ADAR-mediated RNA-editing across tissues
por: Huntley, Melanie A., et al.
Publicado: (2016)

ADAR1-Mediated RNA Editing and Its Role in Cancer
por: Liu, Jizhe, et al.
Publicado: (2022)

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
por: Keegan, Liam P., et al.
Publicado: (2011)

RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing
por: Xing, Yanfang, et al.
Publicado: (2023)

ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site
por: Doherty, Erin E, et al.
Publicado: (2022)

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis
por: Heraud-Farlow, Jacki E., et al.
Publicado: (2017)

RNA editing by the host ADAR system affects the molecular evolution of the Zika virus
por: Piontkivska, Helen, et al.
Publicado: (2017)

Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2
por: Phelps, Kelly J., et al.
Publicado: (2015)

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA
por: Mannion, Niamh M., et al.
Publicado: (2014)

The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster
por: Li, Xianghua, et al.
Publicado: (2014)

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins
por: Mannion, Niamh, et al.
Publicado: (2015)

Genetic Determinants of RNA Editing Levels of ADAR Targets in Drosophila melanogaster
por: Kurmangaliyev, Yerbol Z., et al.
Publicado: (2015)

Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human Diseases
por: Song, Chunzi, et al.
Publicado: (2016)

ADAR1-mediated RNA-editing of 3′UTRs in breast cancer
por: Sagredo, Eduardo A., et al.
Publicado: (2018)

The RNA editing enzyme ADAR2 restricts L1 mobility
por: Frassinelli, Loredana, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r5dfsvcmhs6av2hm8vboo1kkg1