Targeting Discoidin Domain Receptor 1 (DDR1) Signaling and Its Crosstalk with β(1)-Integrin Emerges as a Key Factor for Breast Cancer Chemosensitization upon Collagen Type 1 Binding

Collagen type 1 (COL1) is a ubiquitously existing extracellular matrix protein whose high density in breast tissue favors metastasis and chemoresistance. COL1-binding of MDA-MB-231 and MCF-7 breast cancer cells is mainly dependent on β(1)-integrins (ITGB1). Here, we elucidate the signaling of chemor...

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Detalles Bibliográficos
Autores principales: Baltes, Fabian, Caspers, Julia, Henze, Svenja, Schlesinger, Martin, Bendas, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404217/
https://www.ncbi.nlm.nih.gov/pubmed/32668815
http://dx.doi.org/10.3390/ijms21144956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404217/
https://www.ncbi.nlm.nih.gov/pubmed/32668815
http://dx.doi.org/10.3390/ijms21144956

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