Detection of a G-Quadruplex as a Regulatory Element in Thymidylate synthase for Gene Silencing Using Polypurine Reverse Hoogsteen Hairpins

Thymidylate synthase (TYMS) enzyme is an anti-cancer target given its role in DNA biosynthesis. TYMS inhibitors (e.g., 5-Fluorouracil) can lead to drug resistance through an autoregulatory mechanism of TYMS that causes its overexpression. Since G-quadruplexes (G4) can modulate gene expression, we se...

Descripción completa

Detalles Bibliográficos
Autores principales: Aubets, Eva, J. Félix, Alex, Garavís, Miguel, Reyes, Laura, Aviñó, Anna, Eritja, Ramón, Ciudad, Carlos J., Noé, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404261/
https://www.ncbi.nlm.nih.gov/pubmed/32708710
http://dx.doi.org/10.3390/ijms21145028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404261/
https://www.ncbi.nlm.nih.gov/pubmed/32708710
http://dx.doi.org/10.3390/ijms21145028

Ejemplares similares