Arming Oncolytic Adenoviruses: Effect of Insertion Site and Splice Acceptor on Transgene Expression and Viral Fitness

Oncolytic adenoviruses (OAds) present limited efficacy in clinics. The insertion of therapeutic transgenes into OAds genomes, known as “arming OAds”, has been the main strategy to improve their therapeutic potential. Different approaches were published in the decade of the 2000s, but with few compar...

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Detalles Bibliográficos
Autores principales: Farrera-Sal, Martí, de Sostoa, Jana, Nuñez-Manchón, Estela, Moreno, Rafael, Fillat, Cristina, Bazan-Peregrino, Miriam, Alemany, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404292/
https://www.ncbi.nlm.nih.gov/pubmed/32708234
http://dx.doi.org/10.3390/ijms21145158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404292/
https://www.ncbi.nlm.nih.gov/pubmed/32708234
http://dx.doi.org/10.3390/ijms21145158

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