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ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation
Tumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These signals comprise cytokines and growth factors that are synthesized as trans-membrane proteins and need to be liberated by limited proteolysis...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404302/ https://www.ncbi.nlm.nih.gov/pubmed/32698506 http://dx.doi.org/10.3390/ijms21145133 |
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author | Schumacher, Neele Rose-John, Stefan Schmidt-Arras, Dirk |
author_facet | Schumacher, Neele Rose-John, Stefan Schmidt-Arras, Dirk |
author_sort | Schumacher, Neele |
collection | PubMed |
description | Tumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These signals comprise cytokines and growth factors that are synthesized as trans-membrane proteins and need to be liberated by limited proteolysis also termed ectodomain shedding. Members of the family of A disintegrin and metalloproteases (ADAM) are major mediators of ectodomain shedding and therefore initiators of paracrine signal transduction. In this review, we summarize the current knowledge on how ADAM proteases on tumour cells but also on cells of the tumour micro-environment contribute to the formation of gastrointestinal tumours, and discuss how these processes can be exploited pharmacologically. |
format | Online Article Text |
id | pubmed-7404302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74043022020-08-18 ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation Schumacher, Neele Rose-John, Stefan Schmidt-Arras, Dirk Int J Mol Sci Review Tumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These signals comprise cytokines and growth factors that are synthesized as trans-membrane proteins and need to be liberated by limited proteolysis also termed ectodomain shedding. Members of the family of A disintegrin and metalloproteases (ADAM) are major mediators of ectodomain shedding and therefore initiators of paracrine signal transduction. In this review, we summarize the current knowledge on how ADAM proteases on tumour cells but also on cells of the tumour micro-environment contribute to the formation of gastrointestinal tumours, and discuss how these processes can be exploited pharmacologically. MDPI 2020-07-20 /pmc/articles/PMC7404302/ /pubmed/32698506 http://dx.doi.org/10.3390/ijms21145133 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Schumacher, Neele Rose-John, Stefan Schmidt-Arras, Dirk ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation |
title | ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation |
title_full | ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation |
title_fullStr | ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation |
title_full_unstemmed | ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation |
title_short | ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation |
title_sort | adam-mediated signalling pathways in gastrointestinal cancer formation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404302/ https://www.ncbi.nlm.nih.gov/pubmed/32698506 http://dx.doi.org/10.3390/ijms21145133 |
work_keys_str_mv | AT schumacherneele adammediatedsignallingpathwaysingastrointestinalcancerformation AT rosejohnstefan adammediatedsignallingpathwaysingastrointestinalcancerformation AT schmidtarrasdirk adammediatedsignallingpathwaysingastrointestinalcancerformation |