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ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation

Tumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These signals comprise cytokines and growth factors that are synthesized as trans-membrane proteins and need to be liberated by limited proteolysis...

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Detalles Bibliográficos
Autores principales: Schumacher, Neele, Rose-John, Stefan, Schmidt-Arras, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404302/
https://www.ncbi.nlm.nih.gov/pubmed/32698506
http://dx.doi.org/10.3390/ijms21145133
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author Schumacher, Neele
Rose-John, Stefan
Schmidt-Arras, Dirk
author_facet Schumacher, Neele
Rose-John, Stefan
Schmidt-Arras, Dirk
author_sort Schumacher, Neele
collection PubMed
description Tumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These signals comprise cytokines and growth factors that are synthesized as trans-membrane proteins and need to be liberated by limited proteolysis also termed ectodomain shedding. Members of the family of A disintegrin and metalloproteases (ADAM) are major mediators of ectodomain shedding and therefore initiators of paracrine signal transduction. In this review, we summarize the current knowledge on how ADAM proteases on tumour cells but also on cells of the tumour micro-environment contribute to the formation of gastrointestinal tumours, and discuss how these processes can be exploited pharmacologically.
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spelling pubmed-74043022020-08-18 ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation Schumacher, Neele Rose-John, Stefan Schmidt-Arras, Dirk Int J Mol Sci Review Tumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These signals comprise cytokines and growth factors that are synthesized as trans-membrane proteins and need to be liberated by limited proteolysis also termed ectodomain shedding. Members of the family of A disintegrin and metalloproteases (ADAM) are major mediators of ectodomain shedding and therefore initiators of paracrine signal transduction. In this review, we summarize the current knowledge on how ADAM proteases on tumour cells but also on cells of the tumour micro-environment contribute to the formation of gastrointestinal tumours, and discuss how these processes can be exploited pharmacologically. MDPI 2020-07-20 /pmc/articles/PMC7404302/ /pubmed/32698506 http://dx.doi.org/10.3390/ijms21145133 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schumacher, Neele
Rose-John, Stefan
Schmidt-Arras, Dirk
ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation
title ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation
title_full ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation
title_fullStr ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation
title_full_unstemmed ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation
title_short ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation
title_sort adam-mediated signalling pathways in gastrointestinal cancer formation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404302/
https://www.ncbi.nlm.nih.gov/pubmed/32698506
http://dx.doi.org/10.3390/ijms21145133
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