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Production and Characterization of Anti-Inflammatory Monascus Pigment Derivatives

The prevention and treatment of chronic inflammation using food-derived compounds are desirable from the perspectives of marketing and safety. Monascus pigments, widely used as food additives, can be used as a chronic inflammation treatment. Orange Monascus pigments were produced by submerged fermen...

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Autores principales: Choe, Deokyeong, Song, Soo Min, Shin, Chul Soo, Johnston, Tony V., Ahn, Hyung Jin, Kim, Daehwan, Ku, Seockmo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404703/
https://www.ncbi.nlm.nih.gov/pubmed/32630165
http://dx.doi.org/10.3390/foods9070858
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author Choe, Deokyeong
Song, Soo Min
Shin, Chul Soo
Johnston, Tony V.
Ahn, Hyung Jin
Kim, Daehwan
Ku, Seockmo
author_facet Choe, Deokyeong
Song, Soo Min
Shin, Chul Soo
Johnston, Tony V.
Ahn, Hyung Jin
Kim, Daehwan
Ku, Seockmo
author_sort Choe, Deokyeong
collection PubMed
description The prevention and treatment of chronic inflammation using food-derived compounds are desirable from the perspectives of marketing and safety. Monascus pigments, widely used as food additives, can be used as a chronic inflammation treatment. Orange Monascus pigments were produced by submerged fermentation in a 5 L bioreactor, and multiple orange Monascus pigment derivatives with anti-inflammatory activities were synthesized using aminophilic reaction. A total of 41 types of pigment derivatives were produced by incorporating amines and amino acids into the orange pigments. One derivative candidate that inhibited nitric oxide (NO) production in Raw 264.7 cells and exhibited low cell cytotoxicity was identified via in vitro assay. The 2-amino-4 picoline derivative inhibited NO production of 48.4%, and exhibited cell viability of 90.6%. Expression of inducible NO synthase, an important enzyme in the NO synthesis pathway, was suppressed by such a derivative in a dose-dependent manner. Therefore, this derivative has potential as a functional food colorant with anti-inflammatory effects.
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spelling pubmed-74047032020-08-11 Production and Characterization of Anti-Inflammatory Monascus Pigment Derivatives Choe, Deokyeong Song, Soo Min Shin, Chul Soo Johnston, Tony V. Ahn, Hyung Jin Kim, Daehwan Ku, Seockmo Foods Article The prevention and treatment of chronic inflammation using food-derived compounds are desirable from the perspectives of marketing and safety. Monascus pigments, widely used as food additives, can be used as a chronic inflammation treatment. Orange Monascus pigments were produced by submerged fermentation in a 5 L bioreactor, and multiple orange Monascus pigment derivatives with anti-inflammatory activities were synthesized using aminophilic reaction. A total of 41 types of pigment derivatives were produced by incorporating amines and amino acids into the orange pigments. One derivative candidate that inhibited nitric oxide (NO) production in Raw 264.7 cells and exhibited low cell cytotoxicity was identified via in vitro assay. The 2-amino-4 picoline derivative inhibited NO production of 48.4%, and exhibited cell viability of 90.6%. Expression of inducible NO synthase, an important enzyme in the NO synthesis pathway, was suppressed by such a derivative in a dose-dependent manner. Therefore, this derivative has potential as a functional food colorant with anti-inflammatory effects. MDPI 2020-07-01 /pmc/articles/PMC7404703/ /pubmed/32630165 http://dx.doi.org/10.3390/foods9070858 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choe, Deokyeong
Song, Soo Min
Shin, Chul Soo
Johnston, Tony V.
Ahn, Hyung Jin
Kim, Daehwan
Ku, Seockmo
Production and Characterization of Anti-Inflammatory Monascus Pigment Derivatives
title Production and Characterization of Anti-Inflammatory Monascus Pigment Derivatives
title_full Production and Characterization of Anti-Inflammatory Monascus Pigment Derivatives
title_fullStr Production and Characterization of Anti-Inflammatory Monascus Pigment Derivatives
title_full_unstemmed Production and Characterization of Anti-Inflammatory Monascus Pigment Derivatives
title_short Production and Characterization of Anti-Inflammatory Monascus Pigment Derivatives
title_sort production and characterization of anti-inflammatory monascus pigment derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404703/
https://www.ncbi.nlm.nih.gov/pubmed/32630165
http://dx.doi.org/10.3390/foods9070858
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