Improved Antithrombotic Activity and Diminished Bleeding Side Effect of a PEGylated α(IIb)β(3) Antagonist, Disintegrin

Polymer polyethylene glycol (PEG), or PEGylation of polypeptides improves protein drug stability by decreasing degradation and reducing renal clearance. To produce a pharmaceutical disintegrin derivative, the N-terminal PEGylation technique was used to modify the disintegrin derivative [KGDRR]trimuc...

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Detalles Bibliográficos
Autores principales: Kuo, Yu-Ju, Chang, Yao Tsung, Chung, Ching-Hu, Chuang, Woei-Jer, Huang, Tur-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404706/
https://www.ncbi.nlm.nih.gov/pubmed/32605221
http://dx.doi.org/10.3390/toxins12070426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404706/
https://www.ncbi.nlm.nih.gov/pubmed/32605221
http://dx.doi.org/10.3390/toxins12070426

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