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Improved Antithrombotic Activity and Diminished Bleeding Side Effect of a PEGylated α(IIb)β(3) Antagonist, Disintegrin

Polymer polyethylene glycol (PEG), or PEGylation of polypeptides improves protein drug stability by decreasing degradation and reducing renal clearance. To produce a pharmaceutical disintegrin derivative, the N-terminal PEGylation technique was used to modify the disintegrin derivative [KGDRR]trimuc...

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Detalles Bibliográficos
Autores principales:	Kuo, Yu-Ju, Chang, Yao Tsung, Chung, Ching-Hu, Chuang, Woei-Jer, Huang, Tur-Fu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404706/ https://www.ncbi.nlm.nih.gov/pubmed/32605221 http://dx.doi.org/10.3390/toxins12070426

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