ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis

Lung cancer remains the leading cause of cancer death. Genome sequencing of lung tumors from patients with squamous cell carcinoma has identified SMAD4 to be frequently mutated. Here, we use a mouse model to determine the molecular mechanisms by which Smad4 loss leads to lung cancer progression. Mic...

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Detalles Bibliográficos
Autores principales: Liu, Jian, Cho, Sung-Nam, Akkanti, Bindu, Jin, Nili, Mao, Jianqiang, Long, Weiwen, Chen, Tenghui, Zhang, Yiqun, Tang, Ximing, Wistub, Ignacio I., Creighton, Chad J., Kheradmand, Farrah, DeMayo, Francesco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405934/
https://www.ncbi.nlm.nih.gov/pubmed/25753424
http://dx.doi.org/10.1016/j.celrep.2015.02.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405934/
https://www.ncbi.nlm.nih.gov/pubmed/25753424
http://dx.doi.org/10.1016/j.celrep.2015.02.014

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