Cytomegalovirus Promotes Intestinal Macrophage-mediated Mucosal Inflammation through Induction of Smad7

Intestinal macrophages in healthy human mucosa are profoundly down-regulated for inflammatory responses (inflammation anergy) due to stromal TGF-β inactivation of NF-κB. Paradoxically, in cytomegalovirus (CMV) intestinal inflammatory disease, one of the most common manifestations of opportunistic CM...

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Detalles Bibliográficos
Autores principales: Dennis, Evida A., Smythies, Lesley E., Grabski, Robert, Li, Mao, Ballestas, Mary E., Shimamura, Masako, Sun, Jim J., Grams, Jayleen, Stahl, Richard, Niederweis, Michael E., Britt, William J., Smith, Phillip D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405939/
https://www.ncbi.nlm.nih.gov/pubmed/30076393
http://dx.doi.org/10.1038/s41385-018-0041-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405939/
https://www.ncbi.nlm.nih.gov/pubmed/30076393
http://dx.doi.org/10.1038/s41385-018-0041-4

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