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Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis

The apoptosis that occurs in the immature testis under physiological conditions is necessary for male germ cell development, whereas improper activation of apoptosis can impair spermatogenesis and cause defects in reproduction. We previously demonstrated that in mice, the makorin-2 (Mkrn2) gene is e...

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Detalles Bibliográficos
Autores principales: Qian, Ying-Chen, Xie, Yun-Xia, Wang, Chao-Shan, Shi, Zhu-Mei, Jiang, Cheng-Fei, Tang, Yun-Yi, Qian, Xu, Wang, Lin, Jiang, Bing-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406093/
https://www.ncbi.nlm.nih.gov/pubmed/31489847
http://dx.doi.org/10.4103/aja.aja_76_19