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α-synuclein strains that cause distinct pathologies differentially inhibit proteasome

Abnormal α-synuclein aggregation has been implicated in several diseases and is known to spread in a prion-like manner. There is a relationship between protein aggregate structure (strain) and clinical phenotype in prion diseases, however, whether differences in the strains of α-synuclein aggregates...

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Detalles Bibliográficos
Autores principales: Suzuki, Genjiro, Imura, Sei, Hosokawa, Masato, Katsumata, Ryu, Nonaka, Takashi, Hisanaga, Shin-Ichi, Saeki, Yasushi, Hasegawa, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406352/
https://www.ncbi.nlm.nih.gov/pubmed/32697196
http://dx.doi.org/10.7554/eLife.56825