Solid-phase inclusion as a mechanism for regulating unfolded proteins in the mitochondrial matrix

Proteostasis declines with age, characterized by the accumulation of unfolded or damaged proteins. Recent studies suggest that proteins constituting pathological inclusions in neurodegenerative diseases also enter and accumulate in mitochondria. How unfolded proteins are managed within mitochondria...

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Detalles Bibliográficos
Autores principales: Ruan, Linhao, McNamara, Joshua T., Zhang, Xi, Chang, Alexander Chih-Chieh, Zhu, Jin, Dong, Yi, Sun, Gordon, Peterson, Amy, Na, Chan Hyun, Li, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406381/
https://www.ncbi.nlm.nih.gov/pubmed/32821848
http://dx.doi.org/10.1126/sciadv.abc7288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406381/
https://www.ncbi.nlm.nih.gov/pubmed/32821848
http://dx.doi.org/10.1126/sciadv.abc7288

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