Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity

The mutant gdPT R9K/E129G is a genetically detoxified variant of the pertussis toxin (PTx) and represents an attractive candidate for the development of improved pertussis vaccines. The impact of the mutations on the overall protein structure and its immunogenicity has remained elusive. Here we pres...

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Detalles Bibliográficos
Autores principales: Ausar, Salvador F., Zhu, Shaolong, Duprez, Jessica, Cohen, Michael, Bertrand, Thomas, Steier, Valérie, Wilson, Derek J., Li, Stephen, Sheung, Anthony, Brookes, Roger H., Pedyczak, Artur, Rak, Alexey, Andrew James, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406505/
https://www.ncbi.nlm.nih.gov/pubmed/32759959
http://dx.doi.org/10.1038/s42003-020-01153-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406505/
https://www.ncbi.nlm.nih.gov/pubmed/32759959
http://dx.doi.org/10.1038/s42003-020-01153-3

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